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CAS RN: 498-95-3 | 产品编码: N0420
3-Piperidinecarboxylic Acid
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技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in Water | very faint turbidity |
| NMR | confirm to structure |
物性（参考值）
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | TM6125380 |
运输信息
| HS编码* | 2933.39-000 |
应用
γ-アミノ酪酸 (GABA) 再取り込み阻害剤，ニペコチン酸
Nipecotic acid is a γ-aminobutyric acid (GABA) reuptake inhibitor in vitro, used in scientific research. Some nipecotic acid prodrugs have been synthesized and evaluated for their bioactivity in vivo. It is reported that the R-enantiomer [N0654] is a more potent inhibitor than the S-enantiomer [N0678] of the uptake of GABA.
References
- Inhibition of GABA uptake in rat brain slices by nipecotic acid, isoxazoles, and related compounds
- Uptake of γ-aminobutyric acid by a synaptic vesicle fraction isolated from rat brain
- Fast HPLC estimation of γ-aminobutyric acid in microdialysis perfusates: effect of nipecotic and 3-mercaptopropionic acids
- Synthesis, Stability, and Pharmacological Evaluation of Nipecotic Acid Prodrugs
- GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects
PubMed Literature
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技术规格
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