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CAS RN: 57149-07-2 | 产品编码: N0832
Naftopidil
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 125.0 to 129.0 °C |
物性（参考值）
| 熔点 | 127 °C |
| 水溶性 | 不溶 |
GHS
相关法规
| RTECS# | TL9336500 |
运输信息
| HS编码* | 2933.59-000 |
应用
α1アドレナリン受容体のα1D とα1Aサブタイプ選択的アンタゴニスト，ナフトピジル
Naftopidil is an α1D and α1A subtype-selective α1-adrenoceptor antagonist. The α1-adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein. The receptor consists of three subtypes, including α1A-, α1B-, and α1D-adrenergic. Naftopidil is subtype-selective for the α1D-adrenoceptor with approximately 3- and 17-fold higher affinity than for the α1A- and α1B-adrenoceptor subtypes, respectively. In Japan, naftopidil is used to treat lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH). Recently, it has been reported that naftopidil suppresses human prostate tumor growth. (The product is for research purpose only.)
References
- Naftopidil, a novel α1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human α1-adrenoceptors
- Effects of intrathecal injection of tamsulosin and naftopidil, alpha-1A and -1D adrenergic receptor antagonists, on bladder activity in rats
- The role of naftopidil in the management of benign prostatic hyperplasia (a review)
- Naftopidil, a selective α-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrest
- Naftopidil, a selective α1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma
- Determination of naftopidil enantiomers in rat plasma using chiral solid phases and pre-column derivatization high-performance liquid chromatography
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