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CAS RN: 105816-04-4 | 产品编码: N0912
Nateglinide
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| 产品编码 | N0912 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__9H__2__7NO__3 = 317.43 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 500MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 105816-04-4 |
| Reaxys-RN | 6486870 |
| PubChem物质ID | 160871031 |
| Merck Index (14) | 6428 |
| MDL编号 | MFCD00875706 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -36.5 to -40.0 deg(C=1, 0.1mol/L NaOH) |
物性（参考值）
| 比旋光度 [α]D | -38° (C=1,0.1mol/L NaHO sol.) |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 0.0066 g/l |
GHS
相关法规
| RTECS# | SQ7318950 |
运输信息
| HS编码* | 2924.29-000 |
应用
速効性のATP感受性K+チャンネルアンタゴニスト，ナテグリニド
Nateglinide is a D-phenylalanine derivative which rapidly increases the release of insulin from pancreatic B-cells. More rapidly than that of sulfonylurea antidiabetics, nateglinide inhibits ATP-gated K+ channels and thereby causes depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. (The product is for research purpose only.)
References
- Hypoglycaemic and insulinotropic effects of a novel oral antidiabetic agent, (－)-N-(trans-4-isopropylcyclohexane-carbonyl)-D-phenylalanine (A-4166)
- The effect of food on the oral bioavailability and the pharmacodynamic actions of the insulinotropic agent nateglinide in healthy subjects
- Pancreatic β-cell KATP channel activity and membrane-binding studies with nateglinide: a comparison with sulfonylureas and repaglinide
- Nateglinide (a review)
- Nateglinide quantification in rabbit plasma by HPLC: Optimization and application to pharmacokinetic study
- Development and validation of a stereoselective HPLC method for the determination of the in vitro transport of nateglinide enantiomers in rat intestine
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