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CAS RN: 152520-56-4 | 产品编码: N0954
Nebivolol Hydrochloride
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| 产品编码 | N0954 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__2__2H__2__5F__2NO__4·HCl = 441.90 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿) |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片）, 20MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 152520-56-4 |
| 相关CAS RN
|
118457-14-0 |
| PubChem物质ID | 253661900 |
| Merck Index (14) | 6432 |
| MDL编号 | MFCD07357273 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 223.0 to 228.0 °C |
物性（参考值）
| 熔点 | 226 °C |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
运输信息
| HS编码* | 2932.99-000 |
应用
β1-アドレナリン受容体選択的アンタゴニスト作用と一酸化窒素 (NO) の遊離を介する薬理作用を併せ持つ化合物，ネビボロール塩酸塩
Nebivolol hydrochloride is a third-generation β-adrenergic receptor antagonist (β-blocker). It differs from other β-adrenergic receptor antagonists (propranolol hydrochloride [P0995], carvedilol [C2260], bisoprolol hemifumarate [B3994] and atenolol [A1414]) as it combines highly selective β1-adrenergic receptor antagonist properties with nitric oxide-mediated vasodilatory actions and beneficial effects on endothelial function. (The product is for research purpose only.)
References
- Pharmacological and hemodynamic profile of nebivolol, a chemically novel, potent, and selective β1-adrenergic antagonist
- Nebivolol: a third-generation β-blocker that augments vascular nitric oxide release: endothelial β2-adrenergic receptor-mediated nitric oxide production
- Third-generation β-blockers stimulate nitric oxide release from endothelial cells through ATP efflux
- Pharmacological mechanisms of clinically favorable properties of a selective β1-adrenoceptor antagonist, nebivolol (a review)
- Nebivolol: a highly selective β1-adrenergic receptor blocker that causes vasodilation by increasing nitric oxide (a review)
- RP-HPLC and HPTLC methods for the estimation of nebivolol hydrochloride in tablet dosage form
- A validated UV spectrophotometric method for estimation of nebivolol hydrochloride in bulk and pharmaceutical formulation
参考文献
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