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CAS RN: 912-60-7 | 产品编码: N0963
Noscapine Hydrochloride
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| 产品编码 | N0963 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__2H__2__3NO__7·HCl = 449.88 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,湿气 (吸湿),加热 |
| CAS RN | 912-60-7 |
| 相关CAS RN
|
128-62-1&219533-73-0 |
| PubChem物质ID | 253660822 |
| MDL编号 | MFCD00149223 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on dried substance) |
| Specific rotation [a]20/D | +43.0 to +47.0 deg(C=0.5, 0.1mol/L HCl)(calcd.on dried.substance) |
| Drying loss | max. 9.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 200 °C(dec.) |
| 比旋光度 [α]D | 45° (C=0.5,0.1 mol/L HCl) |
| 溶解性（可溶于） | 乙醇 |
| 溶解性（不溶于） | 乙醚 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | NP7225000 |
运输信息
| HS编码* | 2939.19-000 |
应用
抗腫瘍性イソキノリンアルカロイド，ノスカピン塩酸塩
Noscapine hydrochloride is an isoquinoline alkaloid found in opium latex, not having anesthetic and analgesic properties. Noscapine is being used as an antitussive agent for a long time has been recently discovered as a novel tubulin-binding, anti-angiogenic anticancer agent that causes cell cycle arrest and induces apoptosis in cancer cells. (The product is for research purpose only.)
References
- Noscapine (a review)
- Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells
- Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation
- The anti-cancer activity of noscapine: a review
- A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine
- A review on noscapine, and its impact on heme metabolism
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