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CAS RN: 51803-78-2 | 产品编码: N0984
Nimesulide
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| 产品编码 | N0984 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__3H__1__2N__2O__5S = 308.31 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 51803-78-2 |
| Reaxys-RN | 2421175 |
| PubChem物质ID | 253662461 |
| Merck Index (14) | 6548 |
| MDL编号 | MFCD00079470 |
技术规格
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 148.0 to 152.0 °C |
物性（参考值）
| 熔点 | 150 °C |
| 最大吸收波长 | 391 nm (H__2O) |
| 溶解性（可溶于） | 二甲基甲酰胺 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | PB0970000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2935.90-000 |
应用
比較的選択的なシクロオキシゲナーゼ-2 (COX-2) 阻害剤，ニメスリド
Nimesulide, a sulfonanilide compound, is a relatively selective inhibitor of cyclooxygenase-2 (COX-2) and is used as a non-steroidal anti-inflammatory drug (NSAID). Selective inhibition of COX-2 by NSAIDs may have less gastrointestinal toxicity, while inhibition of COX-1 is linked to gastrointestinal ulcer formation. In addition, nimesulide has some unique therapeutic and pharmacological activities. However, nimesulide induced hepatotoxicity is reported.
References
- In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide. An overview
- Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis
- Nimesulide: some pharmaceutical and pharmacological aspects - an update (a review)
- Nimesulide: an NSAID that preferentially inhibits COX-2, and has various unique pharmacological activities (a review)
- Mechanisms of NSAID-induced hepatotoxicity: focus on nimesulide (a review)
- A review of analytical techniques for determination of oxicams, nimesulide and nabumetone
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