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CAS RN: 159989-65-8 | 产品编码: N0986
Nelfinavir Mesylate
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该产品名称和分子式此前为水合物形式，但由于其水合物没有专属的CAS RN，通常和非水合物共用。
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| 产品编码 | N0986 |
纯度/分析方法 
|
>97.0%(HPLC) |
| 分子式/分子量 | C__3__2H__4__5N__3O__4S·CH__4O__3S = 663.89 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿),加热 |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 159989-65-8 |
| 相关CAS RN
|
159989-64-7 |
| Reaxys-RN | 7407090 |
| PubChem物质ID | 354333524 |
| Merck Index (14) | 6443 |
| MDL编号 | MFCD00931436 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Specific rotation [a]20/D | -111 to -116 deg(C=1, MeOH)(calcd.on anh.substance) |
| Water | 2.0 to 8.0 % |
物性（参考值）
| 比旋光度 [α]D | -112° (C=1,MeOH) |
GHS
| 危险性说明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相关法规
| RTECS# | NW6995333 |
运输信息
| HS编码* | 2933.49-000 |
应用
ヒト免疫不全ウイルス (HIV) プロテアーゼ阻害剤，ネルフィナビルメシル酸塩
Nelfinavir mesylate (AG1343) is a selective inhibitor of the human immunodeficiency virus (HIV) protease which is the enzyme responsible for post-translational processing of HIV propeptides. Inhibition of the viral protease prevents cleavage of the gag and gag-pol polyprotein resulting in the production of immature, non-infectious virus. Nelfinavir in combination with nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide reverse transcriptase inhibitors (NtRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and/or other protease inhibitors profoundly suppresses HIV replication, and helps to increase the number of white blood cells called CD4 (T) cells which help fight off other infections. (The product is for research purpose only.)
Related compounds (NRTIs): Zidovudine [A2052], Lamivudine [L0217], Zalcitabine [D3581], Stavudine [D3580], Didanosine [D3066], Abacavir [A2694], Emtricitabine [E1007]; (NtRTIs): Tenofovir [T3006]; (NNRTIs): Efavirenz [E0997], Nevirapine [N0922].
Related compounds (NRTIs): Zidovudine [A2052], Lamivudine [L0217], Zalcitabine [D3581], Stavudine [D3580], Didanosine [D3066], Abacavir [A2694], Emtricitabine [E1007]; (NtRTIs): Tenofovir [T3006]; (NNRTIs): Efavirenz [E0997], Nevirapine [N0922].
References
- Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease.
- Activities of the human immunodeficiency virus type 1 (HIV-1) protease inhibitor nelfinavir mesylate in combination with reverse transcriptase and protease inhibitors against acute HIV-1 infection in vitro
- Viracept (Nelfinavir Mesylate, AG1343): A Potent, Orally Bioavailable Inhibitor of HIV-1 Protease
- Genotypic and Phenotypic Characterization of Human Immunodeficiency Virus Type 1 Variants Isolated from Patients Treated with the Protease Inhibitor Nelfinavir
- Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV (a review)
- Intracellular measurements of anti-HIV drugs indinavir, amprenavir, saquinavir, ritonavir, nelfinavir, lopinavir, atazanavir, efavirenz and nevirapine in peripheral blood mononuclear cells by liquid chromatography coupled to tandem mass spectrometry
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