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CAS RN: 459789-99-2 | 产品编码: O0641
Obeticholic Acid
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| 产品编码 | O0641 |
| 纯度/分析方法 | >97.0%(GC)(T) |
| 分子式/分子量 | C__2__6H__4__4O__4 = 420.63 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| CAS RN | 459789-99-2 |
| Reaxys-RN | 9238543 |
| MDL编号 | MFCD16621104 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 97.0 % |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 106.0 to 110.0 °C |
| Specific rotation | +3.3 to +5.5 deg(C=1, methanol) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 109 °C |
GHS
相关法规
| RTECS# | FZ2267000 |
运输信息
| HS编码* | 2918.19-000 |
应用
Obeticholic Acid: A Potent and Selective Agonist of Farnesoid X Receptor (FXR)
Farnesoid X receptor (FXR), a nuclear receptor, is a ligand-activated transcription factor involved in the control of bile acid (BA) synthesis and enterohepatic circulation, and a regulator of glucose and lipid metabolism. Obeticholic acid (6-ECDCA, INT-747) is a semi-synthetic mimetic of the primary human bile acid, chenodeoxycholic acid (CDCA) [C0750]. There are reports that obeticholic acid is a potent and selective activator of FXR that reduces hepatic steatosis and fibrosis in animal models of fatty liver disease. (The product is for research purpose only.)
References
- 6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity
- Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: An overview of their mechanisms of action (a review)
- The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer (a review)
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