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CAS RN: 54-71-7 | 产品编码: P0434
Pilocarpine Hydrochloride
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| 产品编码 | P0434 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__1H__1__6N__2O__2·HCl = 244.72 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 应避免的情况 | 光 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 54-71-7 |
| Reaxys-RN | 4034491 |
| PubChem物质ID | 87574632 |
| Merck Index (14) | 7424 |
| MDL编号 | MFCD00012722 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 201.0 to 205.0 °C |
| Specific rotation [a]20/D | +89.0 to +94.0 deg(C=2, H2O) |
| Solubility in Water | almost transparency |
物性（参考值）
| 熔点 | 203 °C |
| 比旋光度 [α]D | 92° (C=2,H2O) |
| 溶解性（不溶于） | 乙醚, 氯仿 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 + H331 : Toxic if swallowed or if inhaled. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相关法规
| RTECS# | TK1450000 |
运输信息
| UN编号 | UN1544 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2939.79-000 |
应用
Pilocarpine Hydrochloride: A Muscarinic Acetylcholine Receptor Agonist
Pilocarpine is an imidazole alkaloid contained in the leaves of Pilocarpus jaborandi and Pilocarpus microphyllus distributed throughout South America. It is a direct acting cholinergic parasympathomimetic agent which acts through direct stimulation of muscarinic acetylcholine receptors (M1, M2, and M3) with low affinity for nicotine receptors. In clinical, formulations of pilocarpine hydrochloride have been used for the treatment of elevated intraocular pressure and dry mouth. (The product is for research purpose only.)
References
- Human M1-, M2- and M3-muscarinic cholinergic receptors: Binding characteristics of agonists and antagonists
- Oral pilocarpine: a review of its pharmacological properties and clinical potential in xerostomia (a review)
参考文献
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