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CAS RN: 58-39-9 | 产品编码: P1970
Perphenazine
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纯度/分析方法: >97.0%(T)(HPLC)
别名：
- 奋乃静
- 2-氯-10-[3-[4-(2-羟基乙基)哌嗪-1-基]丙基]吩噻嗪
- 4-[3-(2-氯吩噻嗪-10-基)丙基]-1-哌嗪乙醇
- 2-Chloro-10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazine
- 4-[3-(2-Chlorophenothiazin-10-yl)propyl]-1-piperazineethanol
产品文档：
技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 95.0 to 99.0 °C |
物性（参考值）
| 熔点 | 97 °C |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 28.3 mg/l 24 °C |
| 溶解性（可溶于） | 丙酮, 乙醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | TL7175000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Perphenazine: A Classical Phenothiazine Typical Antipsychotic
Perphenazine is a classical phenothiazine typical antipsychotic with a potency similar to haloperidol [H0912], a dopamine antagonist. It is extensively metabolized in the liver to a number of metabolites. The pharmacokinetics of perphenazine is mediated by cytochrome P450 2D6 (CYP2D6) and thus is subject to genetic polymorphism. It induces cleft palate in mice fetuses. (The product is for research purpose only.)
References
- Perphenazine (Trilafon) Metabolism in Psychotic Patients
- Steady-state serum concentrations of the neuroleptic perphenazine in relation to CYP2D6 genetic polymorphism
- Pharmacogenetics of classical and new antipsychotic drugs
- Reduction of Drug-Induced Cleft Palate in Mice
参考文献
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技术规格
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