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CAS RN: 48208-26-0 | 产品编码: P2023
N-Phthalyl-L-tryptophan
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| 产品编码 | P2023 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__9H__1__4N__2O__4 = 334.33 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
200MG-Glass Bottle with Plastic Insert （查看图片）, 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 48208-26-0 |
| Reaxys-RN | 4552782 |
| PubChem物质ID | 253661522 |
| MDL编号 | MFCD08705332 |
技术规格
| Appearance | Light yellow to Amber to Dark green powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -268 to -273 deg(C=1, EtOH) |
物性（参考值）
| 熔点 | 181 °C |
| 比旋光度 [α]D | -271° (C=1,EtOH) |
| 溶解性（微溶于） | 甲醇 |
GHS
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
Research on regenerative medicine
RG 108 enhances reprogramming of human1) and mouse2,3) somatic cells to iPS cells.
References
- 1) Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes
- 2) Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells
- 3) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds
应用
RG108: A Non-Nucleoside DNA Methyltransferase (DNMT) Inhibitor
DNA methylation regulates epigenetic gene expression in normal and malignant cells. N-phthaloyl-L-tryptophan (RG108) is a non-nucleoside DNA methyltransferase (DNMT) inhibitor. RG108 significantly reduces the methylation of genomic DNA in cells without any detectable toxicity, distinguishing it from nucleoside-based DNA DNMT inhibitors like 5-azacytidine [A2033], 5-aza-2’-deoxycytidine [A2232] and zebularine [Z0022]. RG108 is useful for the experimental modulation of epigenetic gene regulation.
References
- Epigenetic Reactivation of Tumor Suppressor Genes by a Novel Small-Molecule Inhibitor of Human DNA Methyltransferases
- Functional Diversity of DNA Methyltransferase Inhibitors in Human Cancer Cell Lines
- Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells
- DNA methyltransferase inhibitor RG108 and histone deacetylase inhibitors cooperate to enhance NB4 cell differentiation and E-cadherin re-expression by chromatin remodelling
- Epigenetic-based therapies in cancer: progress to date (a review)
PubMed Literature
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