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CAS RN: 212631-79-3 | 产品编码: P2174
PD 184352
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 5.30 to 6.30 % |
| Melting point | 176.0 to 180.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 178 °C |
GHS
相关法规
运输信息
| HS编码* | 2928.00-000 |
应用
PD184352: A Selective Inhibitor of Mitogen-Activated Protein Kinase (MAPK)
PD184352 (or Cl-1040) is an orally active and selective inhibitor of mitogen-activated protein kinase (MAPK or MAP kinase), a type of serine/threonine protein kinase.
References
- Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
- Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia
- CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK) (a review)
- The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (Cl-1040) selectively induces apoptosis in malignant schwannoma cell lines
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技术规格
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![PD 184352 [Optimized for Cell Culture]](/medias/Tci-300-P3157.jpg?context=bWFzdGVyfHJvb3R8MTE5MzZ8aW1hZ2UvanBlZ3xhRGhpTDJnNVpTODVOVEF6TURBM09EQXhNemMwTDFSamFTMHpNREJmVURNeE5UY3VhbkJufGE1YWZkMDhiY2E1MGQ3NGE3MmQxYmYyMmQ3OTIyOTdiNzAxMWQ0YzgyNTBmZjIyZjUyMWIyNWRmMTJmMDI4ZTQ "PD 184352 [Optimized for Cell Culture]")