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CAS RN: 15574-96-6 | 产品编码: P2344
Pizotifen
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 149 °C |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | TM7165000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Pizotifen: A 5-HT2A and 5-HT2C Receptors antagonist
Pizotifen is a serotonin (5-HT)[S0370] antagonist acting mainly at the 5-HT2A and 5-HT2C receptors. It also acts as a histamine receptor antagonist. In additon, pizotifen has been demonstrated its antiplatelet activity. Its hydrogen malate is used to prevent certain types of headaches such as migraines and cluster headache. (The product is for research purpose only.)
References
- Pharmacological properties of 4(1-methyl-4-piperidylidine)-9,10-dihydro-4H-benzo-[4,5]cyclohepta[1,2]-thiophene hydrogen maleate (pizotifen)
- Pizotifen (BC-105). Review of its pharmacological properties and its therapeutic efficacy in vascular headaches
- Receptors for 5-hydroxytryptamine and noradrenaline in rabbit isolated ear artery and aorta
- Pharmacological properties of the receptor(s) involved in the 5-hydroxytryptamine-induced contraction of the feline middle cerebral artery
- The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function
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