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CAS RN: 100299-08-9 | 产品编码: P2547
Pemirolast Potassium
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| 产品编码 | P2547 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__0H__7KN__6O = 266.31 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 光,加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 100299-08-9 |
| 相关CAS RN
|
69372-19-6 |
| Reaxys-RN | 8097604 |
| PubChem物质ID | 354334415 |
| Merck Index (14) | 7078 |
| MDL编号 | MFCD01690051 |
技术规格
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 317 °C(dec.) |
| 水溶性 | 可溶 |
| 溶解性（不溶于） | 乙醇 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | UV1164470 |
运输信息
| HS编码* | 2933.59-000 |
应用
Pemirolast Potassium: A Water-Soluble Inhibitor of Type I Allergy
Pemirolast potassium is a water-soluble inhibitor of type I allergy. Pharmacological studies indicate that it suppresses the formation of 1,2-diacylglycerol and phosphatidic acid, and the decrease in phosphatidylinositol (PI). It also can stabilize the cell membrane of mast cells, inhibit the inflow and release of Ca2＋, inhibit the activation of phosphodiesterase and increase the intracellular cAMP levels. Recently, some laboratory animal studies reported that it can reduce chemotherapy-induced nausea and vomiting. (The product is for research purpose only.)
References
- Effect of a Novel Antiallergic Drug, Pemirolast, on Activation of Rat Peritoneal Mast Cells: Inhibition of Exocytotic Response and Membrane Phospholipid Turnover
- Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils
- Pemirolast reduces cisplatin-induced kaolin intake in rats
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