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CAS RN: 1445-07-4 | 产品编码: P2939
Pseudouridine (Synthetic)
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纯度/分析方法: >98.0%(HPLC)(qNMR)
别名：
- 假尿苷 (合成)
- 5-(β-D-吡喃核糖基)尿嘧啶 (合成)
- 5-β-D-吡喃核糖基-2,4(1H,3H)-嘧啶二酮 (合成)
- (1S)-1,4-脱水-1-(2,4-二氧代-1,2,3,4-四氢-5-嘧啶基)-D-核糖醇 (合成)
- 5-(β-D-Ribofuranosyl)uracil (Synthetic)
- 5-β-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione (Synthetic)
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产品文档：
| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 100MG |
S$273.00
|
27 | 1 | 下单后约3-4周内可以发货 |
|
| 产品编码 | P2939 |
| 纯度/分析方法 | >98.0%(HPLC)(qNMR) |
| 分子式/分子量 | C__9H__1__2N__2O__6 = 244.20 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 1445-07-4 |
| Reaxys-RN | 621385 |
| MDL编号 | MFCD00038458 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 231 °C |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
Pseudouridine (Ψ): A Modified Pyrimidine Nucleoside Found in RNA
In recent years, numerous studies have demonstrated the outstanding abilities of mRNA to elicit potent immune, making it a viable new platform for vaccine development.1) Additionally there are reports on incorporation of modified nucleobases into mRNA offering advantages for the generation of potent and long-lived antibody responses.2) In protein biosynthesis, pseudouridines, such as pseudouridine (Ψ) [P2939 (synthetic)] [P2396] and 1-methylpseudouridine (m1Ψ) [M3387], are read like uridine (U) and enable comparatively high protein yields.3) Furthermore, pseudouridine has attracted attention for its function in epitranscriptomics, namely the study of RNA modifications.2,4)
References
- 1) The tangled history of mRNA vaccines (a review)
- 2) Chemical Modifications to RNA: A New Layer of Gene Expression Regulation (a review)
- 3) Messenger RNA modifications: Form, distribution, and function (a review)
- 4) Epitranscriptome sequencing technologies: decoding RNA modifications
参考文献
Please visit the Pubchem page at this link.
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