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CAS RN: 116649-85-5 | 产品编码: R0144
Ramatroban
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技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
| Specific rotation | +62.0 to +66.0 deg(C=1, methanol) |
| NMR | confirm to structure |
物性（参考值）
| 溶解性（可溶于） | 乙醇, 甲醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | FE6278500 |
运输信息
| HS编码* | 2935.90-000 |
应用
Ramatroban: A Dual Antagonist of Thromboxane A2 Receptor and Prostaglandin D2 Receptor
Ramatroban (Bay u 3405) is a dual antagonist of thromboxane A2 receptor and prostaglandin D2 receptor. The thromboxane A2 (TXA2) and prostaglandin D2 (PDG2) are allergic substances which cause allergic inflammation. TXA2 is in the family of lipids known as eicosanoids, which are metabolites of arachidonic acid. PGD2 is a major inflammatory mediator produced by mast cells and Th2 cells. Therefore, the antagonist of these substances, ramatroban, has suppressive action of activities of these substances. In clinical, ramatroban is usually used in the treatment of allergic rhinitis. (The product is for research purpose only.)
References
- An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro
- Ramatroban (BAY u 3405): A novel dual antagonist of TXA receptor and CRTh2, a newly identified prostaglandin D2 receptor (a review)
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