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CAS RN: 80214-83-1 | 产品编码: R0164
Roxithromycin
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Elemental analysis(Nitrogen) | 3.10 to 3.60 % |
| Specific rotation [a]20/D | -93.0 to -96.0 deg(C=1, Acetone)(calcd.on anh.substance) |
| Water | max. 3.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 120 °C |
| 比旋光度 [α]D | -95° (C=1,Acetone) |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | KF4990000 |
运输信息
| HS编码* | 2941.90-000 |
应用
Roxithromycin: An Acid-Stable and Enteric Absorbent Semi-Synthetic Macrolide Antibiotic
Macrolide antibiotics are classified by the size of the macrocyclic lactone ring of aglycone as 14-, 15- or 16-membered ring macrolides. Macrolides are characterized by similar chemical structures, mechanisms of action and resistance, but vary in the different pharmacokinetic parameters, and spectrum of activity. Roxithromycin (abbrev: RXM) is chemically synthesized from erythromycin [E0751] to create a more acid-stable antimicrobial and prevents the degradation of the erythromycin base to the hemiketal intermediate. RXM has an in vitro antibacterial profile similar to that of erythromycin. RXM has a pharmacokinetic profile that is characterized by excellent enteric absorption within macrolide antibiotics achieving high concentrations in most tissues and body fluids. In addition, RXM immunomodulatory activities have reported.
References
- A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy
- The new macrolide antibiotics: azithromycin, clarithromycin, dirithromycin, and roxithromycin (a review)
- Roxithromycin: review of its antimicrobial activity
- Analysis of macrolide antibiotics (a review)
- Determination of erythromycin, clarithromycin, roxithromycin, and azithromycin in plasma by high-performance liquidchromatography with amperometric detection
- Mechanism of thymus- and activation-regulated chemokine (TARC)/CCL17 production and its modulation by roxithromycin
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