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CAS RN: 93793-83-0 | 产品编码: R0178
Roxatidine Acetate Hydrochloride
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| 产品编码 | R0178 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__9H__2__8N__2O__4·HCl = 384.90 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 93793-83-0 |
| Reaxys-RN | 5915111 |
| PubChem物质ID | 253661076 |
| Merck Index (14) | 8274 |
| MDL编号 | MFCD00941429 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 146.0 to 150.0 °C |
物性（参考值）
| 熔点 | 148 °C |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | AC3855000 |
运输信息
| HS编码* | 2933.39-000 |
应用
Roxatidine Acetate Hydrochloride: A Specific and Competitive H2-Receptor Antagonist
Roxatidine acetate hydrochloride is a specific and competitive H2-receptor antagonist. Roxatidine acetate and its main metabolite roxatidine inhibit histamine-induced gastric acid secretion with a potency greater than that of cimetidine [C1252] and ranitidine [R0073]. In addition, H2-receptor antagonists such as roxatidine acetate and cimetidine are known to suppress the growth of several tumors including gastrointestinal cancer by reducing vascular endothelial growth factor (VEGF) expression.
References
- A review of the animal pharmacology of roxatidine acetate
- Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic
- Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages
- Determination of roxatidine in human plasma by liquid chromatography/electrospray mass spectrometry and application to a clinical pharmacokinetic study
参考文献
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