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CAS RN: 147098-20-2 | 产品编码: R0180
Rosuvastatin Calcium
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| 产品编码 | R0180 |
纯度/分析方法 
|
>95.0%(HPLC)(N) |
| 分子式/分子量 | C__4__4H__5__4CaF__2N__6O__1__2S__2 = 1,001.14 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 147098-20-2 |
| 相关CAS RN
|
287714-41-4 |
| Reaxys-RN | 7740139 |
| PubChem物质ID | 253661249 |
| Merck Index (14) | 8270 |
| MDL编号 | MFCD04112702 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(with Total Nitrogen) | min. 95.0 % |
| Purity(Chelometric Titration) | min. 90.0 % |
| Specific rotation [a]20/D | -7.0 to -10.0 deg(C=1, CHCL3) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 160 °C |
| 比旋光度 [α]D | -8° (C=1,CHCl3) |
| 最大吸收波长 | 243 nm (Phosphate buffer sol.) |
GHS
相关法规
| RTECS# | MJ9675070 |
运输信息
| HS编码* | 2935.90-000 |
应用
VSV-G lentivirus vector transduction enhancer
Rosuvastatin enhances VSV-G lentiviral transduction of NK Cells.1)
References
- 1) Rosuvastatin enhances VSV-G lentiviral transduction of NK cells via upregulation of the low-density lipoprotein receptor
应用
Rosuvastatin Calcium: A Strong HMG-Coa Reductase Inhibitor (a Strong Statin)
Rosuvastatin calcium is a 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase inhibitor (statin). Compared with most other statins, rosuvastatin possesses a greater number of binding interactions with HMG-CoA reductase and exhibits greater potency in inhibiting enzyme activity and cholesterol synthesis in hepatic cells than other statins. Rosuvastatin is relatively hydrophilic, similar in this respect to pravastatin [P1796]. Rosuvastatin has one of the longest terminal half-life of the statins and is only minimally metabolized by the cytochrome P 450 (CYP 450) enzyme system with no significant involvement of the 3A4 (CYP3A4) enzyme.
References
- Preclinical and clinical pharmacology of rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (a review)
- A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin
- Structural mechanism for statin inhibition of HMG-CoA reductase
- Determination of simvastatin, pravastatin sodium and rosuvastatin calcium in tablet dosage forms by HPTLC
- A new improved RP-HPLC method for assay of rosuvastatin calcium in tablets
PubMed Literature
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