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CAS RN: 162011-90-7 | 产品编码: R0206
Rofecoxib
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| 产品编码 | R0206 |
纯度/分析方法 
|
>98.0%(GC) |
| 分子式/分子量 | C__1__7H__1__4O__4S = 314.36 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 162011-90-7 |
| Reaxys-RN | 8269007 |
| PubChem物质ID | 354335586 |
| Merck Index (14) | 8248 |
| MDL编号 | MFCD00935806 |
技术规格
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 207.0 to 211.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 209 °C |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 472 mg/l 25 °C |
| 溶解性（微溶于） | 甲醇 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | LU5135000 |
运输信息
| HS编码* | 2932.20-000 |
应用
Rofecoxib: A Selective Cyclooxygenase-2 (COX-2) Inhibitor
Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID), and a selective cyclooxygenase-2 (COX-2) inhibitor. The mechanism of action is mainly by inhibition of the enzyme COX in the arachidonic acid metabolism pathway, resulting in reduced prostaglandin synthesis. In theory, a drug that selectively inhibited COX-2 might block inflammation, pain, and fever produced by prostaglandins while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1. For your reference, rofecoxib was withdrawn from the medicine market in 2004 after it was shown that long-term clinical use could increase the risk of heart attack and stroke. (The product is for research purpose only.)
References
- The discovery of rofecoxib, [MK 966, Vioxx®, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor
- Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles
- Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis
- Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial
- Progress in COX-2 inhibitors: a journey so far (a review)
- Determination of rofecoxib, a cyclooxygenase-2 specific inhibitor, in human plasma using high-performance liquid chromatography with post-column photochemical derivatization and fluorescence detection
- Review of the applications of different analytical techniques for coxibs research (a review)
参考文献
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