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CAS RN: 72559-06-9 | 产品编码: R0211
Rifabutin
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| 产品编码 | R0211 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__4__6H__6__2N__4O__1__1 = 847.02 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 72559-06-9 |
| Reaxys-RN | 3584778 |
| PubChem物质ID | 468592785 |
| Merck Index (14) | 8213 |
| MDL编号 | MFCD00866816 |
技术规格
| Appearance | Red to Dark red to Dark purple powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
物性（参考值）
| 熔点 | 156 °C |
| 最大吸收波长 | 493 nm (MeOH) |
| 溶解性（可溶于） | 甲醇 |
| 溶解性（微溶于） | 乙醇 |
GHS
相关法规
| RTECS# | VJ6700000 |
运输信息
| HS编码* | 2941.90-000 |
应用
Rifabutin: a derivative of rifamycin S with anti-mycobacteria activity
Rifabutin is a derivative of rifamycin S [R0200], belonging to the class of ansamycins, with activity against mycobacteria including atypical organisms such as Mycobacterium avium and M. intracellulare, also referred to as Mycobacterium avium-intracellulare complex (MAC). Rifabutin inhibits DNA-dependent RNA polymerase in susceptible strains of Escherichia coli and Bacillus subtilis but not in mammalian cells. (The product is for research purpose only.)
References
- Rifabutin: a review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy
- Rifamycin-Mode of Action, Resistance, and Biosynthesis (a review)
- Update on Rifampin and Rifabutin Drug Interactions
- Determination of twelve antiretroviral agents in human plasma sample using reversed-phase high-performance liquid chromatography
- Identification of rat urinary metabolites of rifabutin using LC-MSn and LC-HR-MS
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