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CAS RN: 138489-18-6 | 产品编码: R0257
Ro 31-8220 Mesylate
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- Ro 31-8220甲磺酸盐
- 双吲哚基马来酰亚胺IX
- 3-[3-[4-(1-甲基-1H-吲哚-3-基)-2,5-二氧代-2,5-二氢-1H-吡咯-3-基]-1H-吲哚-1-基]丙基异硫脲甲磺酸盐
- Bisindolylmaleimide IX
- 3-[3-[4-(1-Methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl Carbamimidothioate Methanesulfonate
产品文档：
| 产品编码 | R0257 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__5H__2__3N__5O__2S·CH__4O__3S = 553.65 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,空气,湿气 (吸湿),加热 |
| CAS RN | 138489-18-6 |
| Reaxys-RN | 5373685 |
| MDL编号 | MFCD03788207 |
技术规格
| Appearance | Orange to Red powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 237.0 to 241.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 239 °C |
GHS
相关法规
| RTECS# | FD3070500 |
运输信息
| HS编码* | 2933.99-000 |
应用
Ro 31-8220 Mesylate: A Potent, Cell-Permeable Inhibitor of Protein Kinase C (PKC)
Ro 31-8220 mesylate (bisindolylmaleimide IX) is a potent, cell-permeable inhibitor of protein kinase C (PKC) isoforms, which is an important element in the signal transduction pathways of a variety of hormones, cytokines, and growth factors.1,2) In addition, Ro 31-8220 mesylate is inhibits glycogen synthase kinase 3.3) There are reports, that Ro 31-8220 mesylate inhibits LRRK2 (Leucine-rich repeat kinase 2) –G2019S that is a promising therapeutic target for the treatment of Parkinson's disease.4,5) (The product is for research purpose only.)
References
- 1) Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
- 2) Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development (a review)
- 3) The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity
- 4) Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- 5) Investigation of leucine-rich repeat kinase 2: Enzymological properties and novel assays
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