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CAS RN: 49763-96-4 | 产品编码: S0905
Stiripentol
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| 产品编码 | S0905 |
纯度/分析方法 
|
>98.0%(GC) |
| 分子式/分子量 | C__1__4H__1__8O__3 = 234.30 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 49763-96-4 |
| Reaxys-RN | 1313047 |
| PubChem物质ID | 253660381 |
| MDL编号 | MFCD00869310 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 75.0 to 79.0 °C |
物性（参考值）
| 熔点 | 77 °C |
GHS
相关法规
| RTECS# | SB3393000 |
运输信息
| HS编码* | 2932.99-000 |
应用
Stiripentol (STP): A Third Generation Antiepileptic Agent with Multiple Mechanisms of Action
Stiripentol (STP), a third generation antiepileptic agent, has multiple mechanisms of action. STP has recently been proved to increase the GABAergic transmission in animal experimental models. STP also acts as a potent inhibitor of CYP3A4, CYP1A2 and CYP2C19 and increases the plasma concentrations of many other antiepileptic agents. (The product is for research purpose only.)
References
- Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: in vitro and in vivo comparison and calculation of in vivo inhibition constants
- Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABAA-receptor channels
- In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism
- The anticonvulsant stiripentol acts directly on the GABAA receptor as a positive allosteric modulator
- Stiripentol (a review)
参考文献
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