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CAS RN: 515-03-7 | 产品编码: S0916
Sclareol
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| 产品编码 | S0916 |
| 纯度/分析方法 | >96.0%(GC) |
| 分子式/分子量 | C__2__0H__3__6O__2 = 308.51 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 515-03-7 |
| Reaxys-RN | 2054148 |
| PubChem物质ID | 253660564 |
| MDL编号 | MFCD00869558 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 96.0 % |
| Melting point | 99.0 to 103.0 °C |
| Specific rotation [a]20/D | -5.0 to -3.0 deg(C=1,CHCl3) |
物性（参考值）
| 熔点 | 101 °C |
| 沸点 | 189 °C/3 mmHg |
| 比旋光度 [α]D | -4° (C=1,CHCl3) |
| 水溶性 | 不溶 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
相关法规
| RTECS# | QK0301900 |
运输信息
| HS编码* | 2906.19-000 |
应用
Sclareol: A Labdane-Type Diterpene with Cytotoxic Activity against Human Leukemic Cell Lines
Sclareol is a labdane-type diterpene, which is used as a fragrance. It has also demonstrated significant cytotoxic activity against human leukemic cell lines. Some bioactive compounds are synthesized from sclareol.
References
- Fragrance material review on sclareol
- Terpenoids from Salvia sclarea
- Labdane type diterpenes down-regulate the expression of c-myc protein, but not of bcl-2, in human leukemia T-cells undergoing apoptosis
- The effect of sclareol on growth and cell cycle progression of human leukemic cell lines
- Synthesis of Ambrox® from (-)-sclareol and (+)-cis-abienol
- First Enantiospecific Synthesis of the Antitumor Marine Sponge Metabolite (-)-15-Oxopuupehenol from (-)-Sclareo
- Direct resistively heated column gas chromatography (Ultrafast module-GC) for high-speed analysis of essential oils of differing complexities
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