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CAS RN: 32986-56-4 | 产品编码: T2503
Tobramycin

技术规格
Appearance | White to Orange to Green powder to crystal |
Purity(Nonaqueous Titration) | min. 94.0 %(calcd.on anh.substance) |
Specific rotation [a]20/D | +138.0 to +148.0 deg(C=4, H2O)(calcd.on anh.substance) |
Water | max. 8.0 % |
物性(参考值)
熔点 | 178 °C |
比旋光度 [α]D | 143° (C=4,H2O) |
水溶性 | 可溶 |
GHS
相关法规
RTECS# | WK2100000 |
运输信息
HS编码* | 2941.90-000 |
应用
RNA aptamer research
References
- Direct Selection of RNA Beacon Aptamers
- Specific binding of aminoglycoside antibiotics to RNA
应用
Tobramycin: An Aminoglycoside Antibiotic Active Against Pseudomonas Aeruginosa
Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius, and is similar in structure to gentamicin [G0383]. Tobramycin interacts with the 30s and 50s subunit of prokaryotic ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Tobramycin is more active than gentamicin against Pseudomonas aeruginosa and active against many gentamicin resistant strains. Recently, inhaled tobramycin is effective in treating chronic Pseudomonas aeruginosa lung infection in cystic fibrosis. (The product is for research purpose only.)
References
- Tobramycin: a review of its antibacterial and pharmacokinetic properties and therapeutic use
- The aminoglycosides: streptomycin, kanamycin, gentamicin, tobramycin, amikacin, netilmicin, and sisomicin (a review)
- Tobramycin Inhalation Powder: a novel drug delivery system for treating chronic Pseudomonas aeruginosa infection in cystic fibrosis
- Tobramycin Inhalation Powder: A Review of Its Use in the Treatment of Chronic Pseudomonas aeruginosa Infection in Patients with Cystic Fibrosis
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