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CAS RN: 4345-03-3 | 产品编码: T2628
D-α-Tocopherol Succinate
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 97.0 % |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 73.0 to 77.0 °C |
| Specific rotation [a]20/D | +3.0 to +5.0 deg(C=8, EtOH) |
物性（参考值）
| 熔点 | 75 °C |
| 比旋光度 [α]D | 4° (C=8,EtOH) |
| 最大吸收波长 | 286 nm (EtOH) |
| 水溶性 | 不溶 |
GHS
相关法规
| RTECS# | EJ9984000 |
运输信息
| HS编码* | 2936.28-000 |
应用
α-Tocopheryl Succinate (α-TOS): an ester of Vitamin E with various biological activities
Vitamin E [T0251] is an antioxidant that protects organism from damage caused by free radicals. In contrast, α-tocopheryl succinate (α-TOS), an ester of Vitamin E, lacks antioxidative ability. Recently, α-TOS comes into focus due to its various biological activities such as induction of apoptosis and activation of protein kinase C.
References
- Inhibition of cell proliferation by α-tocopherol. Role of protein kinase C
- Induction of cancer cell apoptosis by α-tocopheryl succinate: molecular pathways and structural requirements
- Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo
- Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity (a review)
- Vitamin E analogues and immune response in cancer treatment (a review)
参考文献
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