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CAS RN: 105826-92-4 | 产品编码: T2743
Tropisetron Hydrochloride
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| 产品编码 | T2743 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__7H__2__0N__2O__2·HCl = 320.82 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 105826-92-4 |
| 相关CAS RN | 89565-68-4 |
| Reaxys-RN | 8883131 |
| PubChem物质ID | 160871173 |
| Merck Index (14) | 9783 |
| MDL编号 | MFCD00210221 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 285 °C(dec.) |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | NL6012520 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2933.99-000 |
应用
Tropisetron hydrochloride: A Selective Competitive 5-HT3 Receptor Antagonist
Tropisetron hydrochloride is a selective competitive antagonist of 5-hydroxytryptamine 3 (5-HT3) receptor which is a subclass of serotonin receptors. 5-HT3 receptors are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, known as the emetic center of the brain. Therefore, tropisetron is used for the prevention of chemotherapy-induced nausea and vomiting.1,2) Tropisetron is mainly metabolized by cytochrome P450 (CYP) 2D6.3) In 2000’s, it has been reported that tropisetron is also a selective partial agonist at α7 nicotinic acetylcholine receptors (α7nAChRs). 4,5) (The product is for research purpose only.)
References
- 1)Effects of conditioned fear stress on 5-HT release in the rat prefrontal cortex
- 2)Tropisetron: An update of its use in the prevention of chemotherapy-induced nausea and vomiting (a review)
- 3)Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting (a review)
- 4)The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective α7 nicotinic receptor partial agonist
- 5)Molecular dissection of tropisetron, an α7 nicotinic acetylcholine receptor-selective partial agonist
- 6)Simultaneous determination of ondansetron and tropisetron in human plasma using HPLC with UV detection
- 7)HPLC, TLC, and first-derivative spectrophotometry stability-indicating methods for the determination of tropisetron in the presence of its acid degradates
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