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CAS RN: 106463-17-6 | 产品编码: T2749
Tamsulosin Hydrochloride
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| 产品编码 | T2749 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__0H__2__8N__2O__5S·HCl = 444.97 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 106463-17-6 |
| 相关CAS RN
|
106133-20-4 |
| Reaxys-RN | 6896058 |
| PubChem物质ID | 125307965 |
| SDBS (AIST Spectral DB) | 52985 |
| Merck Index (14) | 9049 |
| MDL编号 | MFCD00922997 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -17.5 to -20.5 deg(C=1, H2O) |
物性（参考值）
| 熔点 | 230 °C(dec.) |
| 比旋光度 [α]D | -19° (C=1,H2O) |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | DB2430000 |
运输信息
| HS编码* | 2935.90-000 |
应用
Pharmacology study
References
- Evaluation of the pharmacological selectivity profile of alpha1 adrenoceptor antagonists at prostatic alpha1 adrenoceptors: binding, functional and in vivo studies
- B. A. Kenny, A. M. Miller, I. J. R. Williamson, J. O'Connell, D. H. Chalmers, A. M. Naylor, Br. J. Pharmacol. 1996, 118, 871.
- Pharmacokinetics and plasma protein binding of tamsulosin hydrochloride in rats, dogs, and humans
- H. Matsushima, H. Kamimura, Y. Soeishi, T. Watanabe, S. Higuchi, M. Tsunoo, Drug Metab. Dispos. 1998, 26, 240.
- Comparison of two alpha1-adrenoceptor antagonists, naftopidil and tamsulosin hydrochloride, in the treatment of lower urinary tract symptoms with benign prostatic hyperplasia: a randomized crossover study
参考文献
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