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CAS RN: 130-61-0 | 产品编码: T3102
Thioridazine Hydrochloride
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 5G |
S$151.50
|
9 | 0 | 下单后约2周内可以发货 |
|
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 95.0 % |
| Melting point | 163.0 to 167.0 °C |
物性（参考值）
| 熔点 | 165 °C |
| 最大吸收波长 | 317 nm (EtOH) |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H410 : Very toxic to aquatic life with long lasting effects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P391 : Collect spillage. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | SP2275000 |
运输信息
| UN编号 | UN3077 |
| 类别 | 9 |
| 包装类别 | III |
| HS编码* | 2934.30-000 |
应用
Quorum sensing inhibitor
Reference
- The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors
应用
Thioridazine Hydrochloride: A Phenothiazine Dopamine D2 Receptor Antagonist and an Antibacterial Agent against MDR-TB or XDR-TB
Thioridazine hydrochloride is a phenothiazine dopamine D2 receptor antagonist which has previously been extensively used for its antipsychotic properties, but fell out of favor because of its increasing the risk of arrhythmia from QTc-prolongation. However, recently, there is good evidence to suggest that, in common with other phenothiazine agents, thioridazine has important antibacterial activity and is a potential candidate for development as an antibacterial agent against multi-resistant organisms, such as multidrug-resistant mycobacterium tuberculosis (MDR-TB or XDR-TB). Further, some studies suggest that thioridazine has activity against cancer stem cells (CSCs). (The product is for research purpose only.)
References
- Receptor affinity, neurochemistry and behavioral characteristics of the enantiomers of thioridazine: evidence for different stereoselectivities at D1 and D2 receptors in rat brain
- Promising therapy of XDR-TB/MDR-TB with thioridazine an inhibitor of bacterial efflux pumps (a review)
- Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now! (a review)
- Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections (a review)
- Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells
- Analytical profile of thioridazine and thioridazine hydrochloride (a review on the physical properties, preparation, pharmacokinetics, pharmacology, and analytical methods for the detection of thioridazine)
- Determination of the enantiomers of thioridazine, thioridazine 2-sulfone, and of the isomeric pairs of thioridazine 2-sulfoxide and thioridazine 5-sulfoxide in human plasma
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