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CAS RN: 10405-02-4 | 产品编码: T3305
Trospium Chloride
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| 产品编码 | T3305 |
纯度/分析方法 
|
>98.0%(HPLC)(N) |
| 分子式/分子量 | C__2__5H__3__0ClNO__3 = 427.97 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 10405-02-4 |
| 相关CAS RN
|
47608-32-2 |
| Reaxys-RN | 5899018 |
| PubChem物质ID | 253661222 |
| Merck Index (14) | 9786 |
| MDL编号 | MFCD00865254 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
物性（参考值）
| 熔点 | 262 °C(dec.) |
| 水溶性 | 可溶 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | WH1424000 |
运输信息
| HS编码* | 2933.99-000 |
应用
Trospium chloride: A Muscarinic Receptor Antagonist
Trospium chloride, a quaternary ammonium compound, is a muscarinic receptor antagonist. It binds specifically and with high affinity to muscarinic M1, M2 and M3 receptor subtypes, but not nicotinic receptors. It blocks the contractile effect of acetylcholine on the smooth musculature of urinary bladder through binding linkage to the muscarinic receptors. Therefore, it is used for the treatment of bladder overactivity. Trospium chloride is hydrophilic and does not cross the normal blood-brain barrier in significant amounts, so that it has minimal central anticholinergic activity. Trospium chloride undergoes negligible metabolized by the cytochrome P 450 system, and therefore has a low potential for drug interactions. (The product is for research purpose only.)
References
- Trospium chloride in the management of overactive bladder (a review)
- Muscarinic receptor antagonists for overactive bladder (a review)
- Effects of tolterodine, trospium chloride, and oxybutynin on the central nervous system
- Inhibitory effects of trospium chloride on cytochrome P450 enzymes in human liver microsomes
- Determination of the quaternary ammonium compound trospium in human plasma by LC-MS/MS: Application to a pharmacokinetic study
- New stability-indicating RP-UFLC method for determination of trospium chloride in tablet dosage form
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