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CAS RN: 483-14-7 | 产品编码: T3311
L-Tetrahydropalmatine
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技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 96.0 % |
| Melting point | 140.0 to 144.0 °C |
| Specific rotation [a]20/D | -278.0 to -298.0 deg(C=1, EtOH) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 142 °C |
| 比旋光度 [α]D | -283° (C=1,EtOH) |
| 最大吸收波长 | 280 nm |
GHS
相关法规
| RTECS# | HQ1792500 |
运输信息
| HS编码* | 2933.99-000 |
应用
A Plant Alkaloid Effective in Multidrug Resistant Cancer Cells
L-Tetrahydropalmatine (L-THP or l-THP), the active enantiomer of THP [T3650], is an alkaloid found in several plant species such as Corydalis and Stephania. Corydalis Tuber (Corydalis yanhusuo) containing L-THP has been used for traditional Chinese pain medicine. Since L-THP antagonizes dopamine D1/D2 receptors and acts on dopamine D3 receptors, as well as α-adrenergic and serotonin receptors, it may have utility for treating opioid addiction.1,2) Furthermore, it has been reported that L-THP shows activity against antineoplastic resistant cancer cells.3) (The product is for research purpose only.)
References
- (－)-Tetrahydropalmatine and its analogues as new dopamine receptor antagonists
- l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction (a review)
- The two enantiomers of tetrahydropalmatine are inhibitors of P-gp, but not inhibitors of MRP1 or BCRP
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