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CAS RN: 518-34-3 | 产品编码: T3321
Tetrandrine
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| 产品编码 | T3321 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__3__8H__4__2N__2O__6 = 622.76 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 518-34-3 |
| Reaxys-RN | 79006 |
| PubChem物质ID | 253661357 |
| Merck Index (14) | 9231 |
| MDL编号 | MFCD08689909 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 221.0 to 225.0 °C |
| Specific rotation [a]20/D | +283 to +287 deg(C=1,CHCl3) |
物性（参考值）
| 熔点 | 223 °C |
| 比旋光度 [α]D | 285° (C=1,CHCl3) |
| 最大吸收波长 | 283 nm (EtOH) |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 乙醚 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | XE9350000 |
运输信息
| HS编码* | 2939.79-000 |
应用
Tetrandrine: A Bisbenzylisoquinoline Alkaloid with Broad Pharmacological Activities
Tetrandrine is a bisbenzylisoquinoline alkaloid isolated from the dried root of Stephenia tetrandra S Moore which is a plant indigenous to main land of China that has long been used as a Chinese herb. Recently, several studies have demonstrated that tetrandrine is a calcium channel receptor antagonist. Moreover, tetrandrine exhibits broad pharmacological activities, including antihypertensive, antiarrhythmic and antitumor activities. Tetrandrine has also been shown to inhibit infection of human macrophages, the primary target of Ebola virus, and also showed therapeutic efficacy in mice. (The product is for research purpose only.)
References
- Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin
- Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: Cardiovascular effects and mechanisms of action; Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives; Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases; Potential role of tetrandrine in cancer therapy (reviews)
- Herbal alkaloid tetrandrine: from an ion channel blocker to inhibitor of tumor proliferation (a review)
- Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance
- Lactoferrin-Conjugated Biodegradable Polymersome Holding Doxorubicin and Tetrandrine for Chemotherapy of Glioma Rats
- Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
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