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CAS RN: 4429-63-4 | 产品编码: T3500
Tabersonine
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 它勃宁
- (3aR,3a1S,10bR)-3a-乙基-3a,3a1,4,6,11,12-六氢-1H-吲哚嗪并[8,1-cd]咔唑-5-甲酸甲酯
- Methyl 5α,12β,19α-2,3,6,7-Tetradehydroaspidospermidine-3-carboxylate
- Methyl (3aR,3a1S,10bR)-3a-Ethyl-3a,3a1,4,6,11,12-hexahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate
产品文档：
| 产品编码 | T3500 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__1H__2__4N__2O__2 = 336.44 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,空气,加热 |
| 包装和容器
|
250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 4429-63-4 |
| Reaxys-RN | 50163 |
| MDL编号 | MFCD28140545 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 89.0 to 93.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 91 °C |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | CJ0150000 |
运输信息
| HS编码* | 2939.79-000 |
应用
Tabersonine: An Indole Alkaloid with Neuroprotective Properties
Tabersonine is an indole alkaloid found in the beans of Voacanga africana, a plant traditionally used for religious purposes in Africa. There are reports that tabersonine exhibits specific and synergistic multiple neuroprotective properties, including inhibition of amyloid beta (Aβ) fibril-induced cytotoxicity.1,2) Tabersonine is also an intermediate in the biological and chemical synthesis of indole alkaloids, including the anticancer agent vincristine [V0129].1,3,4) (The product is for research purpose only.)
References
- 1) Tabersonine Inhibits Amyloid Fibril Formation and Cytotoxicity of Aβ(1-42)
- 2) Natural spirocyclic alkaloids and polyphenols as multi target dementia leads (a review)
- 3) Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast
- 4) Vincamine by synthesis and semi-synthesis (a review)
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