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CAS RN: 322-79-2 | 产品编码: T3601
Triflusal
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 96.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 113.0 to 117.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 115 °C |
| 最大吸收波长 | 297 nm (H__2O) |
| 水溶性 | 不溶 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
运输信息
| HS编码* | 2918.29-000 |
应用
Triflusal: An Antiplatelet Aggregation Agent
Triflusal is an antiplatelet aggregation agent having a trifluoromethyl group at the 4-position. It is metabolized to 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) which inhibits cyclogxygenase-1 (COX-1) in platelets. Furthermore, both triflusal and HTB are also able to increase cyclic adenosine monophosphate (cAMP) [A2381] levels in platelets through inhibition of platelet phosphodiesterases which regulate intracellular cAMP levels. Moreover, triflusal enhances the production of NO by neutrophils via stimulation of the constitutive activity of nitric oxide (NO) synthase (cNOS). It is considered that triflusal shows the antiplatelet aggregation activity by these actions. (The product is for research purpose only.)
References
- Triflusal: An Old Drug in Modern Antiplatelet Therapy. Review of Its Action, Use, Safety and Effectiveness
- Determination of triflusal in human plasma by high performance liquid chromatography with automated column switching system
- Simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in rat and human plasma by high-performance liquid chromatography
PubMed Literature
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