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CAS RN: 91161-71-6 | 产品编码: T3677
Terbinafine
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 特比萘芬
- 反-N-(6,6-二甲基-2-庚烯-4-炔基)-N-甲基-1-萘甲胺
- (E)-N,6,6-三甲基-N-(萘-1-基甲基)庚-2-烯-4-炔-1-胺
- trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine
- (E)-N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine
产品文档：
| 产品编码 | T3677 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__1H__2__5N = 291.44 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 91161-71-6 |
| 相关CAS RN | 78628-80-5 |
| Reaxys-RN | 4256376 |
| PubChem物质ID | 468592889 |
| Merck Index (14) | 9156 |
| MDL编号 | MFCD00242672 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 41.0 to 45.0 °C |
物性（参考值）
| 熔点 | 43 °C |
| 溶解性（可溶于） | 甲醇 |
GHS
相关法规
| RTECS# | QJ8600000 |
运输信息
| HS编码* | 2941.90-000 |
应用
Terbinafine: A Potent Non-Competitive Inhibitor of Squalene Epoxidase
Terbinafine and its hydrochloride [D2049], allylamine antifungals, are potent non-competitive inhibitors of fungal squalene epoxidase, a key enzyme in ergosterol biosynthesis. Ergosterol is an essential component of fungal cell membrane, and terbinafine inhibits ergosterol synthesis at the stage of squalene epoxidation. This results in fungal cell death primarily due to the increased membrane permeability mediated by the accumulation of high concentrations of squalene but not due to ergosterol deficiency. (The product is for research purpose only.)
References
- Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase
- The mechanism of action of terbinafine
- Clinical pharmacokinetics of terbinafine (Lamisil)
- Terbinafine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial mycoses
- Terbinafine: a pharmacological and clinical review
- Determination of terbinafine in tissues
- Rapid UHPLC method for simultaneous determination of vancomycin, terbinafine, spironolactone, furosemide and their metabolites: application to human plasma and urine
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