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Published TCIMAIL newest issue No.200 | Product Document Searching Made Easy by 2D Code! | TCI Life Science News December 2025 | [Product Highlights] Catechol-containing Methacrylate Monomer for... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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CAS RN: 609799-22-6 | 产品编码: T3813
Tasimelteon
| 产品编码 | T3813 |
纯度/分析方法
|
>95.0%(qNMR) |
| 分子式/分子量 | C__1__5H__1__9NO__2 = 245.32 |
| 外观与形状(20°C) | 固体 |
储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
包装和容器
|
50MG-Glass Bottle with Plastic Insert (查看图片) |
| CAS RN | 609799-22-6 |
| Reaxys-RN | 15439325 |
| PubChem物质ID | 468592958 |
| MDL编号 | MFCD09033789 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Specific rotation [a]20/D | -41.0 to -46.0 deg(C=1, CHCL3) |
| NMR | confirm to structure |
物性(参考值)
| 熔点 | 78 °C |
| 比旋光度 [α]D | -45° (C=1,CHCl3) |
GHS
相关法规
| RTECS# | TX1450577 |
运输信息
| HS编码* | 2932.99-000 |
应用
Tasimelteon: A Selective Melatonin MT1 and MT2 Receptors Agonist
Tasimelteon (BMS-214778) is a melatonin [M1105] receptor agonist with both high affinity for melatonin MT1 and MT2 receptors, similar to other members of the melatonin receptor agonist including ramelteon [R0216] and agomelatine [A2606]. Characteristically, tasimelteon exhibits a greater affinity for the MT2 as compared to the MT1 receptor. The agonist activity at the MT1 and MT2 receptors has been reported to contribute to its sleep-promoting properties. And then, tasimelteon currently is approved in the United States and the EU for the treatment of the treatment of non-24-hour sleep-wake disorder. (The product is for research purpose only.)
References
- Preclinical pharmacokinetics and metabolism of BMS-214778, a novel melatonin receptor agonist
- Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders (a review)
- Tasimelteon: a selective and unique receptor binding profile
- Tasimelteon: first global approval (a review)
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