Maximum quantity allowed is 999
请选择数量
CAS RN: 50679-08-8 | 产品编码: T3977
Terfenadine
×
![]()
×
纯度/分析方法: >98.0%(HPLC)
别名：
- 特非那定
- α-[4-(1,1-二甲基乙基)苯基]-4-(羟基二苯基甲基)-1-哌啶丁醇
- 1-[4-(叔丁基)苯基]-4-[4-(羟基二苯基甲基)哌啶-1-基]丁-1-醇
- α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol
- 1-[4-(tert-butyl)phenyl]-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol
产品文档：
| 产品编码 | T3977 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__3__2H__4__1NO__2 = 471.69 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 50679-08-8 |
| Reaxys-RN | 5857899 |
| PubChem物质ID | 468593048 |
| MDL编号 | MFCD00079622 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 146.0 to 150.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 148 °C |
| 最大吸收波长 | 260 nm (EtOH) |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 0.0963 mg/l 25 °C |
| 溶解性（可溶于） | 甲醇, 乙醇 |
GHS
相关法规
| RTECS# | TM4969000 |
运输信息
| HS编码* | 2933.39-000 |
应用
Terfenadine: A Prodrug of Fexofenadine with Selective H1-Receptor Antagonist Activity
Terfenadine is a prodrug of fexofenadine [F0698] (HCl salt) which is a non-sedative antihistamine with selective H1-receptor antagonist activity. Terfenadine is metabolized by intestinal CYP3A4 to fexofenadine which competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked. In addition, it has been reported that terfenadine may reach excessive blood levels when the metabolism is too slow; and which can cause cardiac arrhythmias (prolongation of QT-interval). (The product is for research purpose only.)
References
- Fexofenadine: a review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria
- Terfenadine (A review on description, synthesis, physical properties, analysis, stability, polymorphism and crystal habits, and pharmacokinetics)
产品文档 (部分产品的分析图谱无法提供，敬请谅解。)
化学品安全说明书(SDS)
请选择语言。
如需更多帮助，请联系我 们。
技术规格
CoA及其他文档
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
示例 CoA
可下载CoA示例。注：该示例不一定是最新批次的CoA。
目前没有该产品的 CoA 示例。
分析图谱
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
很抱歉，您搜索的分析图谱无法提供。