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CAS RN: 71369-59-0 | 产品编码: T4139
(-)-Talinolol
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纯度/分析方法: >95.0%(T)(HPLC)
别名：
- (-)-他林洛尔
- (S)-1-[4-[3-(叔丁氨基)-2-羟基丙氧基]苯基]-3-环己基脲
- 1-[4-[(2S)-3-(叔丁氨基)-2-羟基丙氧基]苯基]-3-环己基脲
- (S)-1-[4-[3-(tert-Butylamino)-2-hydroxypropoxy]phenyl]-3-cyclohexylurea
- 1-[4-[(2S)-3-(tert-Butylamino)-2-hydroxypropoxy]phenyl]-3-cyclohexylurea
产品文档：
| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 20MG |
S$192.00
|
12 | 19 | 下单后约2周内可以发货 |
|
| 产品编码 | T4139 |
纯度/分析方法 
|
>95.0%(T)(HPLC) |
| 分子式/分子量 | C__2__0H__3__3N__3O__3 = 363.50 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| CAS RN | 71369-59-0 |
| 相关CAS RN
|
57460-41-0 |
| Reaxys-RN | 8353028 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Melting point | 142.0 to 146.0 °C |
| Specific rotation | -9.0 to -11.0 deg(C=0.1, methanol) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 144 °C |
GHS
相关法规
运输信息
| HS编码* | 2924.21-000 |
应用
(-)-Talinolol: A Model Compound for P-Glycoprotein Drug-Drug Interaction Studies
(±)-Talinolol, a β1-selective adrenoceptor antagonist, has been used as a suitable model compound for P-glycoprotein drug-drug interaction studies due to its P-glycoprotein-related active intestinal secretion and lack of any significant metabolism.1,2) (-)-Talinolol is the active (S)-isomer as a β1-selective adrenoceptor antagonist, and can also be used as a model compound for the studies.3,4) (The product is for research purpose only.)
References
- 1) Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: a new type of drug/drug interaction
- 2) P-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans
- 3) Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo
- 4) Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol (a review)
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