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CAS RN: 3424-98-4 | 产品编码: T4158
Telbivudine
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 替比夫定
- L-胸苷
- 1-(2-脱氧-β-L-erythro-呋喃戊糖基)-5-甲基-2,4(1H,3H)-嘧啶二酮
- 1-[(2S,4R,5S)-4-羟基-5-(羟甲基)四氢呋喃-2-基]-5-甲基嘧啶-2,4(1H,3H)-二酮
- L-Thymidine
- 1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
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产品文档：
| 产品编码 | T4158 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__0H__1__4N__2O__5 = 242.23 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 3424-98-4 |
| Reaxys-RN | 754297 |
| MDL编号 | MFCD02683612 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 186.0 to 190.0 °C |
| Specific rotation | -16.0 to -20.0 deg(C=1, water) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 188 °C |
GHS
相关法规
| RTECS# | UV9048500 |
运输信息
| HS编码* | 2934.99-000 |
应用
Telbivudine: An L-Nucleoside Analog of Thymidine with Antiviral Activity
Telbivudine is an L-nucleoside analog of thymidine [T0233] with antiviral activity. There are reports that telbivudine is a potent, specific and selective inhibitor of hepatitis B virus (HBV) replication. Telbivudine 5'-triphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate, thymidine 5'-triphosphate. Incorporation of telbivudine 5'-triphosphate into viral DNA results in DNA chain termination. (The product is for research purpose only.)
Reference
- Antiviral β-L-nucleosides specific for hepatitis B virus infection (a review)
- Telbivudine for the management of chronic hepatitis B virus infection (a review)
- Telbivudine (a review)
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