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CAS RN: 1156-19-0 | 产品编码: T4168
Tolazamide
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 妥拉磺脲
- N-[[(六氢-1H-氮杂环庚烷-1-基)氨基]羰基]-4-甲基苯磺酰胺
- N-(1-氮杂环庚烷基氨基甲酰基)-4-甲基苯磺酰胺
- 1-(六氢-1H-吖庚因-1-基)-3-(甲苯磺酰基)脲
- N-(Azepan-1-ylcarbamoyl)-4-methylbenzenesulfonamide
- N-(1-Azepanylcarbamoyl)-4-methylbenzenesulfonamide
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产品文档：
| 产品编码 | T4168 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__4H__2__1N__3O__3S = 311.40 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 1156-19-0 |
| Reaxys-RN | 1323565 |
| MDL编号 | MFCD00083504 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 163.0 to 167.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 165 °C |
GHS
相关法规
| RTECS# | YT4400000 |
运输信息
| HS编码* | 2935.90-000 |
应用
Tolazamide: A Sulfonylurea (SU) Compound
Tolazamide (U-17835) is a sulfonylurea (SU) compound used in the treatment of non-insulin-dependent diabetes mellitus. Tolazamide appears to lower blood glucose acutely by stimulating the release of insulin from the pancreas, an effect that depends on the function of beta cells in the pancreatic islets. (The product is for research purpose only.)
References
- Potentiation of Insulin Action by a Sulfonylurea in Primary Cultures of Hepatocytes from Normal and Diabetic Rats
- Biological activities of sulfonamides (a review)
- Characterization of tolazamide binding with glycated and normal human serum albumin by using high-performance affinity chromatography
- Screening, library-assisted identification and validated quantification of oral antidiabetics of the sulfonylurea-type in plasma by atmospheric pressure chemical ionization liquid chromatography-mass spectrometry
- Detection of anti-diabetics in equine plasma and urine by liquid chromatography-tandem mass spectrometry
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