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CAS RN: 38194-50-2 | 产品编码: U0099
Sulindac
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 舒林酸
- (Z)-5-氟-2-甲基-1-[(p-甲基亚磺酰基)苯亚甲基]-1H-茚-3-乙酸
- (Z)-2-[5-氟-2-甲基-1-[4-(甲基亚磺酰基)苯亚甲基]-1H-茚-3-基]乙酸
- (Z)-5-Fluoro-2-methyl-1-[(p-methylsulfinyl)benzylidene]-1H-indene-3-acetic Acid
- (Z)-2-[5-Fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl]acetic Acid
产品文档：
| 产品编码 | U0099 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__0H__1__7FO__3S = 356.41 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| CAS RN | 38194-50-2 |
| PubChem物质ID | 354334891 |
| Merck Index (14) | 8982 |
| MDL编号 | MFCD00599589 |
技术规格
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 182.0 to 186.0 °C |
物性（参考值）
| 熔点 | 184 °C |
| 最大吸收波长 | 327 nm (0.05mol/L methanolic HCl) |
| 水溶性 | 不溶 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | NK8226000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2930.90-900 |
应用
Sulindac: A Nonsteroidal Anti-Inflammatory Drug (NSAID) with Unique Metabolisms
Sulindac is a nonsteroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic activities. The mechanism of action, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition. Sulindac is a unique prodrug. Slindac is reversibly metabolized to sulindac sulfide [S0906] which has anti-inflammatory and analgesic properties and is irreversibly metabolized to sulindac sulfone which has been suggested to possess antiproliferative effects against tumors. (The product is for research purpose only.)
References
- The disposition of sulindac
- Chemical and biological studies on indomethacin, sulindac and their analogs (a review)
- Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis
- Sulindac and its derivatives: a novel class of anticancer agents (a review)
- NSAID sulindac and its analog bind RXRα and inhibit RXRα-dependent AKT signaling
- Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
- Sulindac (a review on the synthesis, physical properties, methods of detection, drug metabolism, pharmacokinetics, etc.)
PubMed Literature
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