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CAS RN: 137862-53-4 | 产品编码: V0112
Valsartan
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| 产品编码 | V0112 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__4H__2__9N__5O__3 = 435.53 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 137862-53-4 |
| Reaxys-RN | 7754038 |
| PubChem物质ID | 125307697 |
| SDBS (AIST Spectral DB) | 52923 |
| Merck Index (14) | 9916 |
| MDL编号 | MFCD00865840 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -63.0 to -67.0 deg(C=1, methanol) |
物性（参考值）
| 熔点 | 117 °C |
| 比旋光度 [α]D | -65° (C=1,MeOH) |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | YV9455000 |
运输信息
| HS编码* | 2933.99-000 |
应用
Valsartan: A Competitive and Selective AT1 Receptor Antagonist
Valsartan is a competitive and selective AT1 receptor antagonist. Valsartan inhibits the actions of angiotensin II at the AT1 receptor subtype which is responsible for most of the known effects of angiotensin II, a principal pressor agent. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). Valsartan blocks the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle. Recently, the combination of valsartan and a thiazide diuretic hydrochlorothiazide [H1274] is often use in clinical. (The product is for research purpose only.)
References
- Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype
- Expression, secretion, and inhibition of angiotensin-converting enzyme in cultured human bronchial epithelial cells
- Valsartan: a review of its pharmacology and therapeutic use in essential hypertension
- Valsartan: more than a decade of experience (a review)
- Valsartan/hydrochlorothiazide. A review of its pharmacology, therapeutic efficacy and place in the management of hypertension
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