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CAS RN: 375815-87-5 | 产品编码: V0168
Varenicline Tartrate
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纯度/分析方法: >95.0%(T)
别名：
- 酒石酸伐仑克林
- 7,8,9,10-四氢-6H-6,10-甲桥吖庚因并[4,5-g]喹喔啉(2R,3R)-2,3-二羟基丁二酸
- 7,8,9,10-四氢-6,10-甲桥-6H-吡嗪并[2,3-h][3]苯并氮杂卓酒石酸盐
- 7,8,9,10-Tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline (2R,3R)-2,3-Dihydroxysuccinic Acid
- 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine Tartrate
产品文档：
技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
| Water | max. 5.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 215 °C |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H410 : Very toxic to aquatic life with long lasting effects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P391 : Collect spillage. |
相关法规
| RTECS# | PC5072000 |
运输信息
| UN编号 | UN3077 |
| 类别 | 9 |
| 包装类别 | III |
| HS编码* | 2933.39-000 |
应用
Varenicline Tartrate: A Partial Agonist/Antagonist with Affinity and Selectivity for α4β2 Nicotinic Acetylcholine Receptors
Varenicline tartrate is a partial agonist/antagonist with affinity and selectivity for α4β2 nicotinic acetylcholine receptors. Varenicline binds to α4β2 neuronal nicotinic acetylcholine receptors and stimulates receptor-mediated activity, but at a significantly lower level than nicotine. In other words, varenicline blocks the ability of nicotine to the receptors (antagonist) and thus to stimulate partially the central nervous mesolimbic dopamine system (partial agonist). In clinical, varenicline tartrate is used as an anti-smoking agent. This receptor stimulation is thought to reduce the withdrawal symptoms associated with smoking cessation and the craving for cigarettes. (The product is for research purpose only.)
References
- Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation
- Preclinical pharmacology of the α4β2 nAChR partial agonist varenicline related to effects on reward, mood and cognition
- Development and validation of RP-HPLC method for estimation of varenicline tartrate in bulk drug and tablet dosage form
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