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CAS RN: 255906-59-3 | 产品编码: V0173
VK3-OCH3
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纯度/分析方法: >98.0%(HPLC)
别名：
- VK3-OCH3
- 2-[(2-甲氧基乙基)硫代]-3-甲基萘-1,4-二酮
- 2-[(2-甲氧基乙基)硫代]-3-甲基-1,4-萘二酮
- 2-[(2-甲氧基乙基硫基]-3-甲基萘-1,4-二酮
- 2-[(2-Methoxyethyl)thio]-3-methylnaphthalene-1,4-dione
- 2-[(2-Methoxyethyl)thio]-3-methyl-1,4-naphthoquinone
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产品文档：
| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 50MG |
S$450.00
|
17 | 0 | 下单后约3-4周内可以发货 |
|
技术规格
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 66.0 to 70.0 °C |
| NMR | confirm to structure |
物性（参考值）
GHS
相关法规
运输信息
| HS编码* | 2930.90-900 |
应用
VK3-OCH3: A Thioether Analog of Vitamin K with a Selective Anti-Tumor Activity
VK3-OCH3 is a thioether analog of vitamin K with a selective anti-tumor activity.1-3) It has been reported that VK3-OCH3 inhibits the activity of protein-tyrosine phosphatases (PTPases), and induces protein-tyrosine phosphorylation in a human hepatoma cell line (Hep3 B).1) In another report, VK3-OCH3 induces G2/M arrest and apoptosis through heme oxygenase-1 (HO-1) related signal transduction in neuroblastoma cells and exhibit less cytotoxicitiy in normal cell lines.2) (The product is for research purpose only.)
References
- 1) Inhibition of hepatoma cell growth in vitro by arylating and non-arylating K vitamin analogs. Significance of protein tyrosine phosphatase inhibition
- 2) Vitamin K3 Analogs Induce Selective Tumor Cytotoxicity in Neuroblastoma
- 3) Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25
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