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CAS RN: 298-81-7 | 产品编码: X0009
Xanthotoxin
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| 产品编码 | X0009 |
纯度/分析方法 
|
>98.0%(GC) |
| 分子式/分子量 | C__1__2H__8O__4 = 216.19 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 298-81-7 |
| Reaxys-RN | 196453 |
| PubChem物质ID | 87577878 |
| SDBS (AIST Spectral DB) | 10625 |
| Merck Index (14) | 5988 |
| MDL编号 | MFCD00005009 |
技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 145.0 to 149.0 °C |
物性（参考值）
| 熔点 | 147 °C |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 丙酮 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H302 : Harmful if swallowed. H371 : May cause damage to organs. H373 : May cause damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. H350 : May cause cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | LV1400000 |
运输信息
| HS编码* | 2932.99-000 |
应用
8-Methoxypsoralen (8-MOP): A Photosensitizer in Combination with UV-A irradiation, called PUVA
5-Methoxypsoralen (5-MOP) [B2840], 8-methoxypsoralen (8-MOP) and 4,5',8-trimethylpsoralen [T2267] are naturally occurring linear psoralens (furocoumarins). They have been successfully used as photosensitizers in combination with UV-A irradiation which is called the psoralen-based PUVA (psoralen + UV-A) to manage dermatological diseases, such as psoriasis, vitiligo and cancer. Reportedly, the most important mechanism implies the [2+2] cycloaddition photoreaction of psoralen and a DNA pyrimidine nucleobase. The formation of psoralen-pyrimidine adducts prevents the division of the injured cells. In another photoreaction, the activated psoralen can transfer energy to molecular oxygen to generate reactive radicals or excited singlet oxygen which becomes prone to damage the membrane of the harmed cell. In addition, 5-MOP and 8-MOP work as Cytochrome P450 inhibitors. (The product is for research purpose only.)
References
- The evolution of photochemotherapy with psoralens and UVA (PUVA): 2000 BC to 1992 AD (a review)
- 5-Methoxypsoralen: a review of its effects in psoriasis and vitiligo (a review)
- Photoreactivity of Furocoumarins and DNA in PUVA Therapy: Formation of Psoralen−Thymine Adducts
- Psoralen photobiology and photochemotherapy: 50 years of science and medicine (a review)
- Mechanism-Based Inactivation of Cytochrome P450 2B1 by 8-Methoxypsoralen and Several Other Furanocoumarins
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