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CAS RN: 81938-43-4 | 产品编码: Z0041
Zofenopril Calcium
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技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 246 °C |
GHS
| 危险性说明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
Zofenopril Calcium: An Angiotensin-Converting Enzyme (ACE) Inhibitor
Zofenopril calcium is an angiotensin-converting enzyme (ACE) inhibitor. Zofenopril is prodrug which is rapidly hydrolyzed to the active metabolite zofenoprilat by hepatic cleavage of the thioester group. It has been reported that zofenopril is characterized by high lipophilicity, selective cardiac ACE inhibition, and antioxidant and tissue protective activities. ACE, a peptidyl dipeptidase, circulates in the plasma and is located on the surface of endothelial cells. ACE is catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Thereby, ACE inhibitors reduce peripheral vascular resistance and blood pressure. For your reference, [B5315] is a key synthetic intermediate of zofenopril. (The product is for research purpose only.)
References
- Preclinical profile of zofenopril: an angiotensin converting enzyme inhibitor with peculiar cardioprotective properties (a review)
- Antioxidant and cardioprotective properties of the sulphydryl angiotensinconverting enzyme inhibitor zofenopril
- Simultaneous estimation and validation of some binary mixtures of antihypertensive drugs by RP-LC methods using two new generation silica columns
- Validated UV spectrophotometric method for quantification of zofenopril in pharmaceutical formulations
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