Synthesis of Polysubstituted Olefins

Barluenga et al. have reported the synthesis of polysubstituted olefins using N-tosylhydrazones 1. The reaction of 1 with an equivalent of aryl halide in the presence of a palladium catalyst and a base proceeds to give polysubstituted olefins. In this method, a stoichiometric amount of an organometallic reagent is not required, unlike the Kumada, Negishi, and Stille coupling reactions. Thus, broad future application of this method is expected.