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CAS RN: 520-34-3 | Product Number: D4441
Diosmetin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3',5,7-Trihydroxy-4'-methoxyflavone
- Luteolin 4'-Methyl Ether
- 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€66.00
|
3 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D4441 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__2O__6 = 300.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 520-34-3 |
| Reaxys Registry Number | 294492 |
| PubChem Substance ID | 468591266 |
| MDL Number | MFCD00017425 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 260.0 to 264.0 °C |
Properties (reference)
| Melting Point | 262 °C |
| Maximum Absorption Wavelength | 348 nm (MeOH) |
| Solubility (soluble in) | Acetone, Chloroform, dichloromethane |
GHS
Related Laws:
| EC Number | 208-291-8 |
| RTECS# | DJ2984400 |
Transport Information:
| HS Number | 2932990090 |
Application
Diosmetin: A Flavonoid with Diverse Biological Activities
Diosmetin, the aglycon part of diosmin [D3908], is a flavonoid that has been found in citrus fruits. It has been reported to exert diverse biological activities such as anti-oxidative, anti-inflammatory, anti-apoptotic, and anti-tumor activities.1-4) In addition, it inhibits the cytochrome P450 isoforms CYPA1 and CYP1B1.5) (The product is for research purpose only.)
References
- 1) Intracellular Antioxidant Detoxifying Effects of Diosmetin on 2,2-Azobis(2-amidinopropane) Dihydrochloride (AAPH)-Induced Oxidative Stress through Inhibition of Reactive Oxygen Species Generation
- 2) Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
- 3) A review on pharmacological and analytical aspects of diosmetin: A concise report
- 4) Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer
- 5) Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids
- 6) Simultaneous determination of diosmin and diosmetin in human plasma by ion trap liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: Application to a clinical pharmacokinetic study
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