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Published TCIMAIL newest issue No.199
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CAS RN: 14484-47-0 | Product Number: D4523
Deflazacort
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Purity: >98.0%(HPLC)(N)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€88.00
|
1 | 21 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D4523 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__2__5H__3__1NO__6 = 441.52 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 14484-47-0 |
| Reaxys Registry Number | 4947650 |
| PubChem Substance ID | 253661789 |
| Merck Index (14) | 2862 |
| MDL Number | MFCD00866106 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 256.0 to 260.0 °C |
| Specific rotation [a]20/D | +63.0 to +74.0 deg(C=0.5, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 258 °C |
| Specific Rotation | 73° (C=0.5,CHCl3) |
| Solubility (soluble in) | dichloromethane |
GHS
Related Laws:
| EC Number | 238-483-7 |
| RTECS# | TU4157050 |
Transport Information:
| HS Number | 2937290000 |
Application
Deflazacort: A Synthetic Glucocorticoid with Anti-Inflammatory and Immunosuppressive Activity
Deflazacort is a synthetic glucocorticoid and an oxazoline derivative of prednisolone [P0637] with anti-inflammatory and immunosuppressive activity. Deflazacort is an ester prodrug and metabolized to form the active metabolite 21-desacetyldeflazacort.
References
- Deflazacort. A review of its pharmacological properties and therapeutic efficacy
- Disposition of a new steroidal anti-inflammatory agent, deflazacort, in rat, dog and man
- Deflazacort: a glucocorticoid with few metabolic adverse effects but important immunosuppressive activity
PubMed Literature
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