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Published TCIMAIL newest issue No.199
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CAS RN: 107753-78-6 | Product Number: Z0029
Zafirlukast
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Purity: >98.0%(HPLC)
Synonyms:
- Cyclopentyl N-[3-[[2-Methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]carbamate
- N-[3-[[2-Methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]carbamic Acid Cyclopentyl Ester
- Cyclopentyl [3-[2-Methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl]-1-methyl-1H-indol-5-yl]carbamate
- [3-[2-Methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl]-1-methyl-1H-indol-5-yl]carbamic Acid Cyclopentyl Ester
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€164.00
|
1 | 2 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | Z0029 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__1H__3__3N__3O__6S = 575.68 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 107753-78-6 |
| Reaxys Registry Number | 3641829 |
| PubChem Substance ID | 253661584 |
| Merck Index (14) | 10108 |
| MDL Number | MFCD00864775 |
Specifications
| Appearance | White to Gray to Brown powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
Properties (reference)
| Solubility in water | Insoluble |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (slightly sol. in) | Acetone |
| Solubility (insoluble in) | Toluene, Methanol |
GHS
Related Laws:
| RTECS# | FB3966200 |
Transport Information:
| HS Number | 2935909099 |
Application
Zafirlukast: A Competitive and Selective Peptide Leukotriene Receptor Antagonist
Zafirlukast is a competitive and selective peptide leukotriene receptor antagonist. It binds to the CysLT1 receptors competitively with these cysteinyl leukotrienes (LTC4，LTD4 and LTE4). On the other hand, zafirlukast metabolism by cytochrome P450 3A4 (CYP3A4) has been reported.
References
- The preclinical pharmacology of ICI 204219 (a review)
- Characterization of the human cysteinyl leukotriene CysLT1 receptor
- Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor
- Zafirlukast: a review of its pharmacology and therapeutic potential in the management of asthma
- Zafirlukast Metabolism by Cytochrome P450 3A4 Produces an Electrophilic α,β-Unsaturated Iminium Species That Results in the Selective Mechanism-Based Inactivation of the Enzyme
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